Organic Spectroscopy ((INSTALL))
Organic Spectroscopy presents the derivation of structural information from UV, IR, Raman, 1H NMR, 13C NMR, Mass and ESR spectral data in such a way that stimulates interest of students and researchers alike. The application of spectroscopy for structure determination and analysis has seen phenomenal growth and is now an integral part of Organic Chemistry courses.
Organic Spectroscopy is an invaluable reference for the interpretation of various spectra. It can be used as a basic text for undergraduate and postgraduate students of spectroscopy as well as a practical resource by research chemists. The book will be of interest to chemists and analysts in academia and industry, especially those engaged in the synthesis and analysis of organic compounds including drugs, drug intermediates, agrochemicals, polymers and dyes.
CHEM 5032 - Organic Spectroscopy(3 Cr.) Advanced presentations of identification techniques for organic compounds. Analytical procedures include infrared spectroscopy, nuclear magnetic resonance, mass spectrometry, and ultraviolet-visible spectroscopy. Prerequisites: A C or better in 2032 or equivalent. Spring, even yearsClick here for course scheduling information.
This archive includes six types of problems from the midterm and final exams of my Chem 203 Organic Spectroscopy class. The first three focus on infrared spectroscopy, mass spectrometry, and 1D NMR spectroscopy. The next focuses on using these three techniques together to determine the structures of organic compounds. The last two categories incorporate 2D NMR spectroscopy and are thus considered "advanced." The advanced spectral analysis problems focusing on analyzing 1- and 2D NMR spectra to address questions of stereochemistry. The advanced structure determination problems focus on using all of these techniques to determine the structures of organic compounds.
2014 Midterm Exam Part I.3. (2014-MT-I.3.pdf)Problem Type: Interpret the 1H NMR spectrum of (S)-glycidyl benzyl ether.Techniques: 1H NMR spectroscopy.Notes: This problem gets to the heart of coupling and diastereotopicity. It is one of my all-time favorites.
2013 Midterm Exam Part I.3. (2013-MT-I.3.pdf)Problem Type: Match regioisomeric aromatic compounds with 1H NMR spectra.Techniques: 1H NMR spectroscopy.Notes: This is a great little matching problem that gets to the heart of pattern recognition, coupling, and symmetry in 1H NMR spectroscopy.
2012 Midterm Exam Part I.3. (2012-MT-I.3.pdf)Problem Type: Match the eight constitutional isomeric alcohols C5H12O with 1H NMR and 13C NMR spectra.Techniques: 1H NMR and 13C NMR spectroscopy.Notes: A challenging matching problem that probes concepts of chemical equivalence and symmetry in 1H NMR spectroscopy. One of my favorites.
2011 (fall) Midterm Exam Part I.2a. (2011f-MT-I.2a.pdf)Problem Type: Match the regioisomers of dinitrophenol with 1H NMR spectra.Techniques: 1H NMR and 13C NMR spectroscopy.Notes: A matching problem that probes concepts of chemical equivalence and symmetry in 1H NMR spectroscopy.
CHEM 562 - Organic Spectroscopy Description: Theory, instrumentation and application of spectroscopic techniques in organic chemistry. Focus is primarily on interpretation of data in order to fully characterize molecular structure. Course will not have an established scheduling pattern.Credits: (3)Learner Outcomes: Upon successful completion of this course, the student will be able to:
There are several spectroscopic techniques which can be used to identify organic molecules: infrared (IR), mass spectroscopy (MS) UV/visible spectroscopy (UV/Vis) and nuclear magnetic resonance (NMR).
IR, NMR and UV/vis spectroscopy are based on observing the frequencies of electromagnetic radiation absorbed and emitted by molecules. MS is based on measuring the mass of the molecule and any fragments of the molecule which may be produced in the MS instrument.
Nuclear Magnetic Resonance (NMR) Spectroscopy is one of the most useful analytical techniques for determining the structure of an organic compound. There are two main types of NMR, 1H-NMR (Proton NMR) and 13C-NMR (Carbon NMR). NMR is based on the fact that the nuclei of atoms have a quantized property called spin. When a magnetic field is applied to a 1H or 13C nucleus, the nucleus can align either with (spin +1/2) or against (spin -1/2) the applied magnetic field.
A mass spectroscope measures the exact mass of ions, relative to the charge. Many times, some form of separation is done beforehand, enabling a spectrum to be collected on a relatively pure sample. An organic sample can be introduced into a mass spectroscope and ionised. This also breaks some molecules into smaller fragments.
The wavenumbers of the absorbed IR radiation are characteristic of many bonds, so IR spectroscopy can determine which functional groups are contained in the sample. For example, the carbonyl (C=O) bond will absorb at 1650-1760cm-1.
In each of these problems you are given the IR, NMR, and molecular formula. Using this information, your task is to determine the structure of the compound. The best approach for spectroscopy problems is the following steps:
Problems in NMR and IR Spectroscopy Welcome to WebSpectra - This site was established to provide chemistry students with a library of spectroscopy problems. Interpretation of spectra is a technique that requires practice - this site provides 1H NMR and 13C NMR, DEPT, COSY and IR spectra of various compounds for students to interpret. Hopefully, these problems will provide a useful resource to better understand spectroscopy.
Organic compounds are often identified using spectroscopy. The process of testing compounds using spectroscopy is fairly simple (the compounds are placed into the machine and the read-out is printed). The difficult part comes in learning how to read the print-out and determining what it is telling you.
In infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy, we identify the compound based on specific groups. Certain ranges of frequencies for each type of spectroscopy indicate different groups.
Another form a spectroscopy is mass spectroscopy. This tells us the mass of the compound. There are typically a lot of lines on a mass spectrum, so the important thing is figuring out which lines are useful. Let's take a look at the mass spectrum of our compound:
C-NMR, H-NMR, and IR use known absorbances or peaks to identify specific functional groups on the compound. This can be used to begin identifying the compound. But it can't typically identify the entire compound. Mass spectroscopy tells us the molecular weight of the compound and its fragments.
Thermal degradation is a common technique used to investigate the nature of organic materials. However, existing methods for the Fourier transform infrared (FTIR) identification and quantification of volatile products from the thermal degradation of organic materials are limited to the technique of thermogravimetric analysis (TGA)-FTIR, which utilizes relatively low heating rates. However, the thermal degradation products of organic materials are known to vary depending on the rate of heating, with lower heating rates of biomass associated with increased yields of solid char and decreased yields of volatiles, as well as a greater opportunity for secondary reactions between the residue and the pyrolysis products. Hence, it is difficult to relate the products of organic matter thermally degraded at
CHM 512 - Molecular Modeling (1 hour)An introduction to computational chemistry with an emphasis on the structures and energies of organic systems. Cross listed with CHM 412. For cross-listed undergraduate/graduate courses, the graduate-level course will have additional academic requirements beyond those of the undergraduate course. Prerequisite: C or better in CHM 256.
CHM 526 - Advanced Analytical Chemistry (3 hours)Instrumental analysis, including topics in spectroscopy, electrochemistry, chromatography, sampling, and statistics. Prerequisite: C or better in CHM 420 or CHM 520.
CHM 532 - Descriptive Inorganic Chemistry (3 hours)Preparation, properties, reactions and uses of the main group and transition elements and their compounds. Not open to students with credit in CHM 332. Prerequisite: C or better in CHM 256 and CHM 326.
CHM 536 - Inorganic Chemistry (3 hours)Theoretical and descriptive inorganic chemistry, including atomic structure, molecular structure, coordination chemistry, organometallic chemistry, and catalysis. Cross listed with CHM 436. For cross-listed undergraduate/graduate courses, the graduate-level course will have additional academic requirements beyond those of the undergraduate course. Prerequisite: C or better in CHM 114 or concurrent enrollment; C or better in CHM 256.
CHM 538 - Topics in Inorganic Chemistry (1-6 hours)Topic stated in the current Schedule of Classes. Maximum of 3 hours per semester; may be repeated under different topics for a maximum of six credits. Prerequisite: C or better in CHM 532 or CHM 536.
CHM 540 - Materials Chemistry (3 hours)Study of unit cells, band theory, and the structure, function, and characterization (diffraction, microscopy, and spectroscopy) of metals, polymers, glasses, concrete, ceramics, and biomaterials. Cross listed with CHM 440. For cross-listed undergraduate/graduate courses, the graduate-level course will have additional academic requirements beyond those of the undergraduate course. Prerequisite: C or better in CHM 256 and CHM 257 or consent of instructor.
CHM 550 - Industrial Organic Chemistry (1 hour)Survey of industrial organic chemistry with an emphasis on petroleum derivatives. Cross listed with CHM 450. For cross-listed undergraduate/graduate courses, the graduate-level course will have additional academic requirements beyond those of the undergraduate course. Prerequisite: C or better in CHM 256. 041b061a72